منابع مشابه
Peptidomimetic isoform selective nNOS inhibitors
T he discovery of the cyclic nucleotides 3',5'cyclic monophosphate (cAMP, Prod. No. A 9501, A 4137) and guanosine 3',5'-cyclic monophosphate (cGMP, Prod. No. G 7504, G 6129) led to the first formulation of the second messenger concept. These cyclic nucleotides are now known to be ubiquitous intracellular second messengers that mediate the response of cells to a variety of extracellular stimuli ...
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Serine proteases (SP), such as thrombin, factor Xa, elastase, trypsin are implicated in many clinical disorders such as emphysema, arthritis and cardiovascular diseases. These enzymes, in normal physiological conditions, are regulated by naturally occurring serine protease inhibitors, such as anti-thrombin III involved in thromb in inhibition. Primitive parasitic invertebrates have co-evolved h...
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The serine protease thrombin is the effector enzyme of blood coagulation. It has many activities critical for the formation of stable clots, including cleavage of fibrinogen to fibrin, activation of platelets and conversion of procofactors to active cofactors. Thrombin carries-out its multiple functions by utilising three special features: a deep active site cleft and two anion binding exosites...
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Chemotherapy of leishmaniasis is mainly based on antimonials. However, they are extremely toxic and cause serious side effects, and there is a worldwide increasing frequency of chemoresistance to antimonials. These issues emphasize the urgent need for affordable alternative drugs against leishmaniasis. Leishmania cysteine proteases are essential for parasite growth, differentiation, pathogenici...
متن کاملDevelopment of Direct Thrombin Inhibitors
Anticoagulants are the cornerstone of therapy for conditions associated with arterial and venous thrombosis. Direct thrombin inhibitors (DTIs) are anticoagulants that bind to thrombin and block its enzymatic activity. The bivalent parenteral DTIs hirudin and bivalirudin were based on the observation that the salivary extracts of medicinal leeches prevented blood from clotting. Key events that f...
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ژورنال
عنوان ژورنال: Pathophysiology of Haemostasis and Thrombosis
سال: 2003
ISSN: 1424-8832,1424-8840
DOI: 10.1159/000083850